Article
Mediastinal paragangliomas: association with mutations in the succinate dehydrogenase genes and aggressive behavior.
Endocrine-related cancer - 1 Mar 2009
Ghayee Hans K, Havekes Bas, Corssmit Eleonora P M, Eisenhofer Graeme, Hammes Stephen R, Ahmad Zahid, Tessnow Alexander, Lazúrová Ivica, Adams Karen T, Fojo Antonio T, Pacak Karel, Auchus Richard J
Abstract excerpt
Extra-adrenal pheochromocytomas, otherwise known as paragangliomas (PGLs), account for about 20% of catecholamine-producing tumors. Catecholamine excess and mutations in the genes encoding succinate dehydrogenase subunits (SDHx) are frequently found in patients with PGLs. Only 2% of PGLs are found in the mediastinum, and little is known about genetic alterations in patients with mediastinal PGLs, catecholamine...
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