Article
A Patient with an Extra-adrenal Pheochromocytoma and Germ-line SDHB Mutation Accompanied by an Atypical Meningioma.
Internal medicine (Tokyo, Japan) - 1 Jan 2015
Shiwa Tsuguka, Oki Kenji, Yoneda Masayasu, Arihiro Koji, Ohno Haruya, Kishimoto Rui, Kohno Nobuoki
Abstract excerpt
The gene succinate dehydrogenase subunit B (SDHB) encodes a protein comprising part of the mitochondrial complex II, which links the Krebs cycle and the electron-transport chain. Heterozygous germ-line SDHB mutations causes familial pheochromocytoma-paraganglioma syndrome and has also been linked to gastrointestinal stromal tumors, as well as renal cell carcinomas. We herein report a patient with a germ-line SDHB...
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