Article
Selective serotonin reuptake inhibitor attenuates the hyperresponsiveness of TLR2+ and TLR4+ Th17/Tc17-like cells in multiple sclerosis patients with major depression.
Immunology - 1 Mar 2021
Sales Marisa C, Kasahara Taissa M, Sacramento Priscila M, Rossi Átila D, Cafasso Marcos Octávio S D, Oyamada Hugo A A, Hygino Joana, Alvim Fabianna, Andrade Regis M, Cristina Vasconcelos Cláudia, Bento Cleonice A M
Abstract excerpt
Elevated frequency of Th17-like cells expressing Toll-like receptors (TLRs) has been recently associated with relapsing-remitting multiple sclerosis (MS) pathogenesis, a chronic inflammatory demyelinating autoimmune disease of the central nervous system. We aimed to investigate the impact of current major depressive disorder (MDD) on the behaviour of these cells following in vitro stimulation with TLR2, TLR4,...
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