Article
Pharmacogenetic profiling of dihydropyrimidine dehydrogenase (DPYD) variants in the Indian population.
The journal of gene medicine - 1 Jan 2021
Naushad Shaik Mohammad, Hussain Tajamul, Alrokayan Salman A, Kutala Vijay Kumar
Abstract excerpt
BACKGROUND: The present study aimed to delineate the pharmacologically relevant dihydropyrimidine dehydrogenase (DPYD) variants in the Indian population. METHODS: We screened 2000 Indian subjects for DPYD variants using the Infinium Global Screening Array (GSA) (Illumina Inc., San Diego, CA, USA). RESULTS: The GSA analysis identified seven coding, two intronic and three synonymous DPYD variants. Level 1A alleles...
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