Pharmacogenetic DPYD allele variant frequencies: A comprehensive analysis across an ancestrally diverse Iranian population.

doi:10.1007/s40199-024-00538-7

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Article

Pharmacogenetic DPYD allele variant frequencies: A comprehensive analysis across an ancestrally diverse Iranian population.

Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences - 1 Dec 2024

Sarhangi Negar, Rouhollah Fatemeh, Niknam Negar, Sharifi Farshad, Nikfar Shekoufeh, Larijani Bagher, Patrinos George P, Hasanzad Mandana

Abstract excerpt

BACKGROUND: Cancer treatment has improved over the past decades, but many cancer patients still experience adverse drug reactions (ADRs). Pharmacogenomics (PGx), known as personalized treatment, is a pillar of precision medicine that aims to optimize the efficacy and safety of medications by studying the germline variations. Germline variations in the DPYD lead to significant ADRs. The present cross-sectional...

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PMID: 39424756
DOI: 10.1007/s40199-024-00538-7
PMCID: PMC11555172

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