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Article

Frequency of DPYD gene variants and phenotype inference in a Southern Brazilian population.

Annals of human genetics - 1 Mar 2022

Botton Mariana Rodrigues, Hentschke-Lopes Marina, Matte Ursula

Abstract excerpt

Fluoropyrimidines are chemotherapy drugs that may cause severe adverse events, and their metabolism occurs by dihydropyrimidine deydrogenase (DPD), coded by DPYD. Variants in the DPYD were associated to a greater risk of toxicity. Our aim was to determine the frequency of the most relevant DPYD alleles according to CPIC guidelines (DPYD*2A-rs3918290, DPYD*13-rs55886062, rs67376798, and HapB3-rs75017182) in a...

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Identifiers

PMID: 34897655
DOI: 10.1111/ahg.12453

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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