Article
Pharmacogenetic landscape of DPYD variants in south Asian populations by integration of genome-scale data.
Pharmacogenomics - 1 Feb 2018
Hariprakash Judith M, Vellarikkal Shamsudheen K, Keechilat Pavithran, Verma Ankit, Jayarajan Rijith, Dixit Vishal, Ravi Rowmika, Senthivel Vigneshwar, Kumar Anoop, Sehgal Paras, Sonakar Akhilesh K, Ambawat Sakshi, Giri Anil K, Philip Arun, Sivadas Akhila, Faruq Mohammed, Bharadwaj Dwaipayan, Sivasubbu Sridhar, Scaria Vinod
Abstract excerpt
AIM: Adverse drug reactions to 5-Fluorouracil(5-FU) is frequent and largely attributable to genetic variations in the DPYD gene, a rate limiting enzyme that clears 5-FU. The study aims at understanding the pharmacogenetic landscape of DPYD variants in south Asian populations. MATERIALS & METHODS: Systematic analysis of population scale genome wide datasets of over 3000 south Asians was performed. Independent...
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