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Article

A mutation in C. neoformans mitochondrial NADH dehydrogenase results in increased virulence in mice.

Virulence - 1 Dec 2020

Merryman Mitch, Crigler Jacob, Seipelt-Thiemann Rebecca, McClelland Erin

Abstract excerpt

Cryptococcus neoformans: (H99W) was serially passaged in the invertebrate wax moth Galleria mellonella fifteen times to study how fungal virulence evolves under selection and whether those adaptations affect virulence. The G. mellonella passaged strain (P15) and the pre-passage H99W strains were used to infect three different host models of C. neoformans: C. elegans, G. mellonella, and Balb/c mice. While there...

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Identifiers

PMID: 33103620
DOI: 10.1080/21505594.2020.1831332
PMCID: PMC7588220

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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