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Article

Effect of serotonin transporter genotype on carbon dioxide-induced fear-related behavior in mice.

Journal of psychopharmacology (Oxford, England) - 1 Dec 2020

Leibold Nicole K, van den Hove Daniel LA, Weidner Magdalena T, Buchanan Gordon F, Steinbusch Harry Wm, Lesch Klaus-Peter, Schruers Koen Rj

Abstract excerpt

BACKGROUND: Inhaling 35% carbon dioxide induces an emotional and symptomatic state in humans closely resembling naturally occurring panic attacks, the core symptom of panic disorder. Previous research has suggested a role of the serotonin system in the individual sensitivity to carbon dioxide. In line with this, we previously showed that a variant in the SLC6A4 gene, encoding the serotonin transporter, moderates...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33103571
DOI: 10.1177/0269881120959611
PMCID: PMC7708670

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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