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Article

Amiloride-sensitive cation channel 2 genotype affects the response to a carbon dioxide panic challenge.

Journal of psychopharmacology (Oxford, England) - 1 Oct 2017

Leibold Nicole K, van den Hove Daniel LA, Viechtbauer Wolfgang, Kenis Gunter, Goossens Liesbet, Lange Iris, Knuts Inge, Smeets Hubert J, Myin-Germeys Inez, Steinbusch Harry Wm, Schruers Koen Rj

Abstract excerpt

Until recently, genetic research into panic disorder (PD) has had only limited success. Inspired by rodent research, demonstrating that the acid-sensing ion channel 1a (ASIC1a) is critically involved in the behavioral fear response to carbon dioxide (CO2) exposure, variants in the human homologue gene amiloride-sensitive cation channel 2 (ACCN2) were shown to be associated with PD. However, the relationship...

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PMID: 28121219
DOI: 10.1177/0269881116686880

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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