Article
Genetic moderation of CO2-induced fear by 5-HTTLPR genotype.
Journal of psychopharmacology (Oxford, England) - 1 Jan 2011
Schruers Koen, Esquivel Gabriel, van Duinen Marlies, Wichers Marieke, Kenis Gunter, Colasanti Alessandro, Knuts Inge, Goossens Lies, Jacobs Nele, van Rozendaal Jalet, Smeets Hubert, van Os Jim, Griez Eric
Abstract excerpt
Inhalation of an increased concentration of carbon dioxide (CO(2)) has been shown to induce a state of negative affect in healthy subjects that is closely related to the clinical phenomenon of panic. It has been suggested that the vulnerability to CO(2) is moderated by differences in serotonin (5-HT) activity, caused by a functional polymorphism in the promoter region of the 5-HT transporter (5-HTTLPR) gene. Our...
Topics
- Adult
- Alleles
- Carbon Dioxide
- Cross-Over Studies
- Dose-Response Relationship, Drug
- Double-Blind Method
- Fear
- Female
- Genotype
- Humans
- Male
- Middle Aged
- Panic Disorder
- Polymorphism, Genetic