Article
The human ortholog of acid-sensing ion channel gene ASIC1a is associated with panic disorder and amygdala structure and function.
Biological psychiatry - 1 Dec 2014
Smoller Jordan W, Gallagher Patience J, Duncan Laramie E, McGrath Lauren M, Haddad Stephen A, Holmes Avram J, Wolf Aaron B, Hilker Sidney, Block Stefanie R, Weill Sydney, Young Sarah, Choi Eun Young, Rosenbaum Jerrold F, Biederman Joseph, Faraone Stephen V, Roffman Joshua L, Manfro Gisele G, Blaya Carolina, Hirshfeld-Becker Dina R, Stein Murray B, Van Ameringen Michael, Tolin David F, Otto Michael W, Pollack Mark H, Simon Naomi M, Buckner Randy L, Ongür Dost, Cohen Bruce M
Abstract excerpt
BACKGROUND: Individuals with panic disorder (PD) exhibit a hypersensitivity to inhaled carbon dioxide, possibly reflecting a lowered threshold for sensing signals of suffocation. Animal studies have shown that carbon dioxide-mediated fear behavior depends on chemosensing of acidosis in the amygdala via the acid-sensing ion channel ASIC1a. We examined whether the human ortholog of the ASIC1a gene, ACCN2, is...
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