The NLRP3 inflammasome activation in human or mouse cells, sensitivity causes puzzle

Abstract excerpt

According to our current understanding, the NLR family, pyrin domain containing 3 (NLRP3) infl ammasome activation is generally a two-step process.The fi rst step is priming, in which pathogen associated molecular patterns (PAMPs) such as LPS or pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α) induced NF-κB activation provides synthesis of pro-IL-1β and NLRP3 proteins.This priming step is...

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