Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Qualification of tumour mutational burden by targeted next-generation sequencing as a biomarker in hepatocellular carcinoma.

Liver international : official journal of the International Association for the Study of the Liver - 1 Jan 2021

Wong Ching Ngar, Fessas Petros, Dominy Kathy, Mauri Francesco A, Kaneko Takahiro, Parcq Persephone Du, Khorashad Jamshid, Toniutto Pierluigi, Goldin Robert D, Avellini Claudio, Pinato David J

Abstract excerpt

BACKGROUND & AIMS: Tumour mutational burden (TMB) predicts improved response and survival to immunotherapy. In this pilot study, we optimized targeted next-generation sequencing (tNGS) to estimate TMB in hepatocellular carcinoma (HCC). METHODS: We sequenced 48 non-paired samples (21 fresh-frozen [FF] and 27 paraffin-embedded [FFPE]), among which 11 FFPE samples were pretreated with uracil-DNA glycosylase (UDG)....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers, Tumor
Share to Cancer Genomics and Diagnostics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Hepatocellular

Share to Hepatocellular Carcinoma Treatment and Prognosis

Share to High-Throughput Nucleotide Sequencing

Share to Liver Neoplasms

Share to Mutation

Share to Pilot Projects

Source

Identifiers

PMID: 33098208
DOI: 10.1111/liv.14706

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Qualification of tumour mutational burden by targeted next-generation sequencing as a biomarker in hepatocellular carcinoma.PMID 33098208Read ↗

Tumor Mutational Burden for Predicting Prognosis and Therapy Outcome of Hepatocellular Carcinoma.Semantic proximity Read ↗

Profile and Predictors of Blood Tumor Mutational Burden in Advanced Hepatocellular Carcinoma.Semantic proximity Read ↗

Expert consensus on the detection and clinical application of tumor mutational burden.Semantic proximity Read ↗

Influence of low tumor content on tumor mutational burden estimation by whole-exome sequencing and targeted panel sequencing.Semantic proximity Read ↗

Estimating tumor mutational burden across multiple cancer types using whole-exome sequencingSemantic proximity Read ↗

A quantitative universal NGS-based ctDNA assay for hepatoblastomaSemantic proximity Read ↗

Applications of molecular barcode sequencing for the detection of low-frequency variants in circulating tumour DNA from hepatocellular carcinoma.Semantic proximity Read ↗

Targeted Next-Generation Sequencing of Plasma Cell-Free DNA in Korean Patients with Hepatocellular Carcinoma.Semantic proximity Read ↗

Genetic profiling using plasma-derived cell-free DNA in therapy-naïve hepatocellular carcinoma patients: a pilot study.Semantic proximity Read ↗

Implications of driver genes associated with a high tumor mutation burden identified using next‑generation sequencing on immunotherapy in hepatocellular carcinomaSemantic proximity Read ↗

Genetic profiling of hepatocellular carcinoma using next-generation sequencing.Semantic proximity Read ↗

Pangenome References Improve Biomarker Estimation from Tumor Sequencing DataSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.