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Article

Intra-tumour heterogeneity of diffuse large B-cell lymphoma involves the induction of diversified stroma-tumour interfaces.

EBioMedicine - 1 Nov 2020

Sangaletti Sabina, Iannelli Fabio, Zanardi Federica, Cancila Valeria, Portararo Paola, Botti Laura, Vacca Davide, Chiodoni Claudia, Di Napoli Arianna, Valenti Cesare, Rizzello Celeste, Vegliante Maria Carmela, Pisati Federica, Gulino Alessandro, Ponzoni Maurilio, Colombo Mario Paolo, Tripodo Claudio

Abstract excerpt

BACKGROUND: Intra-tumour heterogeneity in lymphoid malignancies encompasses selection of genetic events and epigenetic regulation of transcriptional programs. Clonal-related neoplastic cell populations are unsteadily subjected to immune editing and metabolic adaptations within different tissue microenvironments. How tissue-specific mesenchymal cells impact on the diversification of aggressive lymphoma clones is...

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Share to Genetic Heterogeneity
Share to Immunophenotyping

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to In Situ Hybridization

Share to Lymphoma, Large B-Cell, Diffuse

Share to Sequence Analysis, RNA

Share to Stromal Cells

Share to Transcriptome

Share to Tumor Microenvironment

Source

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Identifiers

PMID: 33096480
DOI: 10.1016/j.ebiom.2020.103055
PMCID: PMC7581880

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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