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Article

Enrichment and mutation detection of circulating tumor cells from blood samples.

Oncology reports - 1 Jun 2018

Kou Ruqin, Zhao Jian, Gogoi Priya, Carskadon Shannon, Chow Will, Hwang Clara, Palanisamy Nallasivam, Leung Conrad, Wang Yixin

Abstract excerpt

The potential of circulating tumor cells (CTCs) in the diagnosis and prognosis of cancer patients has become increasingly attractive. However, molecular analysis of CTCs is hindered by low sensitivity and a high level of background leukocytes in CTC enrichment technologies. We have developed a novel protocol using a microfluidic device, which enriches and retrieves CTCs from blood samples. The principle of CTC...

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Identifiers

PMID: 29620284
DOI: 10.3892/or.2018.6342
PMCID: PMC5983925

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