Article
F2R Polymorphisms and Clopidogrel Efficacy and Safety in Patients With Minor Stroke or TIA.
Neurology - 5 Jan 2021
Pan Yuesong, Wangqin Runqi, Li Hao, Wang Yilong, Meng Xia, Johnston S Claiborne, Simon Tabassome, Lin Jinxi, Zhao Xingquan, Liu Liping, Wang David, Wang Yongjun
Abstract excerpt
OBJECTIVE: To investigate the association between protease-activated receptor-1 (PAR-1) gene F2R polymorphisms and efficacy of clopidogrel for minor stroke or TIA. METHODS: Three single nucleotide polymorphisms (CYP2C19*2 [681G>A, rs4244285], CYP2C19*3 [636G>A, rs4986893], and F2R [IVSn-14 A/T, rs168753]) were genotyped among 2,924 patients randomized to clopidogrel plus aspirin (n = 1,461) or aspirin alone (n =...
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