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Article

A polygenic heterogeneity model for common epilepsies with complex genetics.

Genes, brain, and behavior - 1 Oct 2007

Dibbens L M, Heron S E, Mulley J C

Abstract excerpt

Approximately 40% of epilepsy has a complex genetic basis with an unknown number of susceptibility genes. The effect of each susceptibility gene acting alone is insufficient to account for seizure phenotypes, but certain numbers or combinations of variations in susceptibility genes are predicted to raise the level of neuronal hyperexcitability above a seizure threshold for a given individual in a given...

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PMID: 17559416
DOI: 10.1111/j.1601-183X.2007.00333.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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