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Article

Computational analysis of single nucleotide polymorphisms (SNPs) in PPAR gamma associated with obesity, diabetes and cancer.

Journal of biomolecular structure & dynamics - 1 Mar 2022

Stalin Antony, Lin Ding, Josephine Princy Johnson, Feng Yue, Xiang Haiping, Ignacimuthu Savarimuthu, Chen Yuan

Abstract excerpt

The single nucleotide polymorphisms (SNPs) are the common genetic variations in human genomes and act as markers for molecular susceptibility of complex traits and diseases in humans. Amino acid variations in the non-synonymous SNPs (nsSNPs) in coding and non-coding regions affect the function/structure of the proteins. The Peroxisome proliferator-activated receptor gamma (PPARγ or PPARG) is a nuclear receptor...

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PMID: 33089758
DOI: 10.1080/07391102.2020.1835724

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