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Article

Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes.

Proceedings of the National Academy of Sciences of the United States of America - 9 Sept 2014

Majithia Amit R, Flannick Jason, Shahinian Peter, Guo Michael, Bray Mark-Anthony, Fontanillas Pierre, Gabriel Stacey B, Rosen Evan D, Altshuler David

Abstract excerpt

Peroxisome proliferator-activated receptor gamma (PPARG) is a master transcriptional regulator of adipocyte differentiation and a canonical target of antidiabetic thiazolidinedione medications. In rare families, loss-of-function (LOF) mutations in PPARG are known to cosegregate with lipodystrophy and insulin resistance; in the general population, the common P12A variant is associated with a decreased risk of type...

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Share to Adipocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25157153
DOI: 10.1073/pnas.1410428111
PMCID: PMC4246964

Genes

PPARG
MAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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