Article
Association of FMO3 rs1736557 polymorphism with clopidogrel response in Chinese patients with coronary artery disease.
European journal of clinical pharmacology - 1 Mar 2021
Zhu Kong-Xiang, Song Pei-Yuan, He-Li, Li Mu-Peng, Du Yin-Xiao, Ma Qi-Lin, Peng Li-Ming, Chen Xiao-Ping
Abstract excerpt
PURPOSE: Dual antiplatelet therapy with aspirin and clopidogrel is commonly used for coronary artery disease (CAD) patients undergoing percutaneous coronary intervention to prevent stent thrombosis and ischemic events. However, some patients show high on-treatment platelet reactivity (HTPR) during clopidogrel therapy. Genetic factors such as loss-of-function variants of CYP2C19 are validated to increase the risk...
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