Article
Two genetic variants in the promoter region of the CCL5 gene are associated with the risk of acute coronary syndrome and with a lower plasma CCL5 concentration.
Immunology letters - 1 Dec 2020
Herrera-Maya Gabriel, Vargas-Alarcon Gilberto, Ramirez-Bello Julian, Perez-Mendez Oscar, Posadas-Sanchez Rosalinda, Lopez-Marure Rebeca, Granados Julio, Nieto-Lima Betzabe, Fragoso Jose Manuel
Abstract excerpt
Acute coronary syndrome (ACS) is a multi-factorial condition with a strong inflammatory component, which is immune-mediated by chemokines. The CCL5 is a chemokine that has been suggested to be an important participant in the development of the atherosclerotic plaque. Therefore, in this work, we evaluated whether three polymorphisms located in the promoter region of the CCL5 gene [CCL5 -28 G/C (rs2280788),...
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