Article
LncRNA U90926 is dispensable for the development of obesity-associated phenotypes in vivo.
Physiological reports - 1 Jan 2024
Sabikunnahar Bristy, Caldwell Sydney, Varnum Stella, Hogan Tyler, Lahue Karolyn G, Rathkolb Birgit, Gerlini Raffaele, Dragano Nathalia R V, Aguilar-Pimentel Antonio, Irmler Martin, Sanz-Moreno Adrián, da Silva-Buttkus Patricia, Beckers Johannes, Wolf Eckhard, Gailus-Durner Valerie, Fuchs Helmut, Hrabe de Angelis Martin, Ather Jennifer L, Poynter Matthew E, Krementsov Dimitry N
Abstract excerpt
Obesity is a global health problem characterized by excessive fat accumulation, driven by adipogenesis and lipid accumulation. Long non-coding RNAs (lncRNAs) have recently been implicated in regulating adipogenesis and adipose tissue function. Mouse lncRNA U90926 was previously identified as a repressor of in vitro adipogenesis in 3T3-L1 preadipocytes. Consequently, we hypothesized that, in vivo, U90926 may...
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