Article
Comparative genomics of closely related Salmonella enterica serovar Typhi strains reveals genome dynamics and the acquisition of novel pathogenic elements.
BMC genomics - 20 Nov 2014
Yap Kien-Pong, Gan Han Ming, Teh Cindy Shuan Ju, Chai Lay Ching, Thong Kwai Lin
Abstract excerpt
BACKGROUND: Typhoid fever is an infectious disease of global importance that is caused by Salmonella enterica subsp. enterica serovar Typhi (S. Typhi). This disease causes an estimated 200,000 deaths per year and remains a serious global health threat. S. Typhi is strictly a human pathogen, and some recovered individuals become long-term carriers who continue to shed the bacteria in their faeces, thus becoming...
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