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Article

Balanced Wnt/Dickkopf-1 signaling by mesenchymal vascular progenitor cells in the microvascular niche maintains distal lung structure and function.

American journal of physiology. Cell physiology - 1 Jan 2021

Summers Megan E, Richmond Bradley W, Kropski Jonathan A, Majka Sarah A, Bastarache Julie A, Hatzopoulos Antonis K, Bylund Jeffery, Ghosh Moumita, Petrache Irina, Foronjy Robert F, Geraghty Patrick, Majka Susan M

Abstract excerpt

The well-described Wnt inhibitor Dickkopf-1 (DKK1) plays a role in angiogenesis as well as in regulation of growth factor signaling cascades in pulmonary remodeling associated with chronic lung diseases (CLDs) including emphysema and fibrosis. However, the specific mechanisms by which DKK1 influences mesenchymal vascular progenitor cells (MVPCs), microvascular endothelial cells (MVECs), and smooth muscle cells...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33085496
DOI: 10.1152/ajpcell.00277.2020
PMCID: PMC7846975

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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