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Discovery of Prenyltransferase Inhibitors with In Vitro and In Vivo Antibacterial Activity

21 Oct 2020

Abstract excerpt

Cis -prenyltransferases such as undecaprenyl diphosphate synthase (UPPS) and decaprenyl diphosphate synthase (DPPS) are essential enzymes in bacteria and are involved in cell wall biosynthesis. UPPS and DPPS are absent in the human genome, so they are of interest as targets for antibiotic development. Here, we screened a library of 750 compounds from National Cancer Institute Diversity Set V for the inhibition of...

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PMID: 33085463
DOI: 10.1021/acsinfecdis.0c00472

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