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Article

Consequences of Zmat3 loss in c-MYC- and mutant KRAS-driven tumorigenesis.

Cell death & disease - 20 Oct 2020

Best Sarah A, Vandenberg Cassandra J, Abad Etna, Whitehead Lachlan, Guiu Laia, Ding Sheryl, Brennan Margs S, Strasser Andreas, Herold Marco J, Sutherland Kate D, Janic Ana

Abstract excerpt

TP53 is a critical tumor suppressor that is mutated in approximately 50% of human cancers. Unveiling the downstream target genes of TP53 that fulfill its tumor suppressor function is an area of intense investigation. Zmat3 (also known as Wig-1 or PAG608) is one such downstream target of p53, whose loss in hemopoietic stem cells lacking the apoptosis and cell cycle regulators, Puma and p21, respectively, promotes...

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Identifiers

PMID: 33082333
DOI: 10.1038/s41419-020-03066-9
PMCID: PMC7575595

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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