Guanosine triphosphate links MYC-dependent metabolic and ribosome programs in small-cell lung cancer.

doi:10.1172/JCI139929

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Article

Guanosine triphosphate links MYC-dependent metabolic and ribosome programs in small-cell lung cancer.

The Journal of clinical investigation - 4 Jan 2021

Huang Fang, Huffman Kenneth E, Wang Zixi, Wang Xun, Li Kailong, Cai Feng, Yang Chendong, Cai Ling, Shih Terry S, Zacharias Lauren G, Chung Andrew, Yang Qian, Chalishazar Milind D, Ireland Abbie S, Stewart C Allison, Cargill Kasey, Girard Luc, Liu Yi, Ni Min, Xu Jian, Wu Xudong, Zhu Hao, Drapkin Benjamin, Byers Lauren A, Oliver Trudy G, Gazdar Adi F, Minna John D, DeBerardinis Ralph J

Abstract excerpt

MYC stimulates both metabolism and protein synthesis, but how cells coordinate these complementary programs is unknown. Previous work reported that, in a subset of small-cell lung cancer (SCLC) cell lines, MYC activates guanosine triphosphate (GTP) synthesis and results in sensitivity to inhibitors of the GTP synthesis enzyme inosine monophosphate dehydrogenase (IMPDH). Here, we demonstrated that primary MYChi...

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Identifiers

PMID: 33079728
DOI: 10.1172/JCI139929
PMCID: PMC7773395

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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