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Article

Human neural stem cell replacement therapy for amyotrophic lateral sclerosis by spinal transplantation.

PloS one - 1 Jan 2012

Hefferan Michael P, Galik Jan, Kakinohana Osamu, Sekerkova Gabriela, Santucci Camila, Marsala Silvia, Navarro Roman, Hruska-Plochan Marian, Johe Karl, Feldman Eva, Cleveland Don W, Marsala Martin

Abstract excerpt

BACKGROUND: Mutation in the ubiquitously expressed cytoplasmic superoxide dismutase (SOD1) causes an inherited form of Amyotrophic Lateral Sclerosis (ALS). Mutant synthesis in motor neurons drives disease onset and early disease progression. Previous experimental studies have shown that spinal grafting of human fetal spinal neural stem cells (hNSCs) into the lumbar spinal cord of SOD1(G93A) rats leads to a...

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Identifiers

PMID: 22916141
DOI: 10.1371/journal.pone.0042614
PMCID: PMC3423406

Genes

SOD1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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