Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Computational SNP Analysis and Molecular Simulation Revealed the Most Deleterious Missense Variants in the NBD1 Domain of Human ABCA1 Transporter.

International journal of molecular sciences - 14 Oct 2020

Dash Raju, Ali Md Chayan, Rana Md Liton, Munni Yeasmin Akter, Barua Largess, Jahan Israt, Haque Mst Fatema, Hannan Md Abdul, Moon Il Soo

Abstract excerpt

The ATP-binding cassette transporter A1 (ABCA1) is a membrane-bound exporter protein involved in regulating serum HDL level by exporting cholesterol and phospholipids to load up in lipid-poor ApoA-I and ApoE, which allows the formation of nascent HDL. Mutations in the ABCA1 gene, when presents in both alleles, disrupt the canonical function of ABCA1, which associates with many disorders related to lipid...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphate
Share to ATP Binding Cassette Transporter 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Binding Sites

Share to Molecular Dynamics Simulation

Share to Mutation, Missense

Share to Phenotype

Share to Polymorphism, Single Nucleotide

Share to Protein Binding

Source

Open in PubMed Open full text

Identifiers

PMID: 33066695
DOI: 10.3390/ijms21207606
PMCID: PMC7589834

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Computational SNP Analysis and Molecular Simulation Revealed the Most Deleterious Missense Variants in the NBD1 Domain of Human ABCA1 Transporter.PMID 33066695Read ↗

Delineating the impact of pathogenic mutations on the conformational dynamics of HDL's vital protein ApoA1: a combined computational and molecular dynamic simulation approach.Semantic proximity Read ↗

In silico analysis of nsSNPs in ABCB1 gene affecting breast cancer associated protein P-glycoprotein (P-gp).Semantic proximity Read ↗

Identification and Molecular Simulation of Genetic Variants in ABCA1 Gene Associated with Susceptibility to Dyslipidemia in Type 2 Diabetes.Semantic proximity Read ↗

Identification of molecular signatures and molecular dynamics simulation of highly deleterious missense variants of key autophagy regulator beclin 1: a computational based approach.Semantic proximity Read ↗

Computational SNP analysis: current approaches and future prospects.Semantic proximity Read ↗

Accurate prediction of the functional significance of single nucleotide polymorphisms and mutations in the ABCA1 gene.Semantic proximity Read ↗

Computational analysis of functional single nucleotide polymorphisms associated with the CYP11B2 gene.Semantic proximity Read ↗

A Comprehensive In Silico Analysis of the Functional and Structural Impact of Nonsynonymous SNPs in the ABCA1 Transporter GeneSemantic proximity Read ↗

Exploring the impact of CYP11A1's missense SNPs on the interaction between CYP11A1 and cholesterol: A comprehensive structural analysis and MD simulation study.Semantic proximity Read ↗

Functional non-synonymous polymorphisms prediction methods: current approaches and future developments.Semantic proximity Read ↗

Non-neutral nonsynonymous single nucleotide polymorphisms in human ABC transporters: the first comparison of six prediction methods.Semantic proximity Read ↗

Phenotype prediction of non-synonymous single-nucleotide polymorphisms in human ATP-binding cassette transporter genes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.