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Article

Sex-Specific Genetic Determinants of Right Ventricular Structure and Function.

American journal of respiratory and critical care medicine - 1 Jan 2025

Harbaum Lars, Hennigs Jan K, Pott Julian, Ostermann Jonna, Sinning Christoph R, Sau Arunashis, Sieliwonczyk Ewa, Ng Fu Siong, Rhodes Christopher J, Tello Khodr, Klose Hans, Gräf Stefan, Wilkins Martin R

Abstract excerpt

Rationale: Although sex differences in right heart phenotypes have been observed, the molecular drivers remain unknown. Objectives: To provide biological insights into sex differences in the structure and function of the right ventricle (RV) using common genetic variation. Methods: RV phenotypes were obtained from cardiac magnetic resonance imaging in 18,156 women and 16,171 men from the UK Biobank. Observational...

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Aged
Genome-Wide Association Study
Heart Ventricles
Magnetic Resonance Imaging
Sex Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ventricular Function, Right

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Identifiers

PMID: 39374572
DOI: 10.1164/rccm.202404-0721OC
PMCID: PMC11755371

Genes

BMPR1A
PAH
DMRT2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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