Article
A new perspective on the interaction between the Vg/VGLL1-3 proteins and the TEAD transcription factors.
Scientific reports - 15 Oct 2020
Mesrouze Yannick, Aguilar Gustavo, Bokhovchuk Fedir, Martin Typhaine, Delaunay Clara, Villard Frédéric, Meyerhofer Marco, Zimmermann Catherine, Fontana Patrizia, Wille Roman, Vorherr Thomas, Erdmann Dirk, Furet Pascal, Scheufler Clemens, Schmelzle Tobias, Affolter Markus, Chène Patrick
Abstract excerpt
The most downstream elements of the Hippo pathway, the TEAD transcription factors, are regulated by several cofactors, such as Vg/VGLL1-3. Earlier findings on human VGLL1 and here on human VGLL3 show that these proteins interact with TEAD via a conserved amino acid motif called the TONDU domain. Surprisingly, our studies reveal that the TEAD-binding domain of Drosophila Vg and of human VGLL2 is more complex and...
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