A MicroRNA Linking Human Positive Selection and Metabolic Disorders.

doi:10.1016/j.cell.2020.09.017

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Article

A MicroRNA Linking Human Positive Selection and Metabolic Disorders.

Cell - 29 Oct 2020

Wang Lifeng, Sinnott-Armstrong Nasa, Wagschal Alexandre, Wark Abigail R, Camporez Joao-Paulo, Perry Rachel J, Ji Fei, Sohn Yoojin, Oh Justin, Wu Su, Chery Jessica, Moud Bahareh Nemati, Saadat Alham, Dankel Simon N, Mellgren Gunnar, Tallapragada Divya Sri Priyanka, Strobel Sophie Madlen, Lee Mi-Jeong, Tewhey Ryan, Sabeti Pardis C, Schaefer Anne, Petri Andreas, Kauppinen Sakari, Chung Raymond T, Soukas Alexander, Avruch Joseph, Fried Susan K, Hauner Hans, Sadreyev Ruslan I, Shulman Gerald I, Claussnitzer Melina, Näär Anders M

Abstract excerpt

Positive selection in Europeans at the 2q21.3 locus harboring the lactase gene has been attributed to selection for the ability of adults to digest milk to survive famine in ancient times. However, the 2q21.3 locus is also associated with obesity and type 2 diabetes in humans, raising the possibility that additional genetic elements in the locus may have contributed to evolutionary adaptation to famine by...

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Identifiers

PMID: 33058756
DOI: 10.1016/j.cell.2020.09.017
PMCID: PMC8092355

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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