Article
USF3 modulates osteoporosis risk by targeting WNT16, RANKL, RUNX2, and two GWAS lead SNPs rs2908007 and rs4531631.
Human mutation - 1 Jan 2021
Ye Weiyuan, Wang Ya, Hou Sasa, Mei Bing, Liu Xinhong, Huang Han, Zhou Qian, Niu Yajing, Chen Yuanyuan, Zhang Manling, Huang Qingyang
Abstract excerpt
Osteoporotic fractures cause major morbidity and mortality in the aging population. Genome-wide association studies (GWAS) have identified USF3 as the novel susceptibility gene of osteoporosis. However, the functional role in bone metabolism and the target gene of the basic helix-loop-helix transcription factor USF3 are unclear. Here, we show that USF3 enhances osteoblast differentiation and suppresses...
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