Article
Genome-wide association study reveals new insights into the heritability and genetic correlates of developmental dyslexia.
Molecular psychiatry - 1 Jul 2021
Gialluisi Alessandro, Andlauer Till F M, Mirza-Schreiber Nazanin, Moll Kristina, Becker Jessica, Hoffmann Per, Ludwig Kerstin U, Czamara Darina, Pourcain Beate St, Honbolygó Ferenc, Tóth Dénes, Csépe Valéria, Huguet Guillaume, Chaix Yves, Iannuzzi Stephanie, Demonet Jean-Francois, Morris Andrew P, Hulslander Jacqueline, Willcutt Erik G, DeFries John C, Olson Richard K, Smith Shelley D, Pennington Bruce F, Vaessen Anniek, Maurer Urs, Lyytinen Heikki, Peyrard-Janvid Myriam, Leppänen Paavo H T, Brandeis Daniel, Bonte Milene, Stein John F, Talcott Joel B, Fauchereau Fabien, Wilcke Arndt, Kirsten Holger, Müller Bent, Francks Clyde, Bourgeron Thomas, Monaco Anthony P, Ramus Franck, Landerl Karin, Kere Juha, Scerri Thomas S, Paracchini Silvia, Fisher Simon E, Schumacher Johannes, Nöthen Markus M, Müller-Myhsok Bertram, Schulte-Körne Gerd
Abstract excerpt
Developmental dyslexia (DD) is a learning disorder affecting the ability to read, with a heritability of 40-60%. A notable part of this heritability remains unexplained, and large genetic studies are warranted to identify new susceptibility genes and clarify the genetic bases of dyslexia. We carried out a genome-wide association study (GWAS) on 2274 dyslexia cases and 6272 controls, testing associations at the...
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