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Hypervirulent pneumococcal serotype 1 harbours two pneumolysin variants with differential haemolytic activity

14 Oct 2020

Abstract excerpt

Streptococcus pneumoniae is a devastating global pathogen. Prevalent in sub-Saharan Africa, pneumococcal serotype 1 is atypical in that it is rarely found as a nasopharyngeal coloniser, yet is described as one of the most common causes of invasive pneumococcal disease. Clonal sequence type (ST)-306 and ST615 are representative of the two major serotype 1 lineages A and C, respectively. Here we investigated the...

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PMID: 33057054
DOI: 10.1038/s41598-020-73454-w

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