Article
SOX1 down-regulates β-catenin and reverses malignant phenotype in nasopharyngeal carcinoma.
Molecular cancer - 26 Nov 2014
Guan Zhong, Zhang Jialiang, Wang Jing, Wang Hefei, Zheng Feimeng, Peng Jieren, Xu Yaodong, Yan Min, Liu Bing, Cui Bai, Huang Ying, Liu Quentin
Abstract excerpt
BACKGROUND: Aberrant activation of the Wnt/β-catenin signaling pathway is an important factor in the development of nasopharyngeal carcinoma (NPC). Previous studies have demonstrated that the developmental gene sex-determining region Y (SRY)-box 1 (SOX1) inhibits cervical and liver tumorigenesis by interfering with the Wnt/β-catenin signaling pathway. However, the role of SOX1 in NPC remains unclear. This study...
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