Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PAI-1-Dependent Inactivation of SMAD4-Modulated Junction and Adhesion Complex in Obese Endometrial Cancer

1 Oct 2020

Abstract excerpt

While plasminogen activator inhibitor-1 (PAI-1) is known to potentiate cellular migration via proteolytic regulation, this adipokine is implicated as an oncogenic ligand in the tumor microenvironment. To understand the underlying paracrine mechanism, here, we conduct transcriptomic analysis of 1,898 endometrial epithelial cells (EECs) exposed and unexposed to PAI-1-secreting adipose stromal cells. The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Angiogenesis and VEGF in Cancer
Share to Cell Adhesion Molecules Research
Share to TGF-β signaling in diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33053339
DOI: 10.1016/j.celrep.2020.108253

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PAI-1-Dependent Inactivation of SMAD4-Modulated Junction and Adhesion Complex in Obese Endometrial CancerPMID 33053339Read ↗

ZEB1 Promotes Invasiveness of Colorectal Carcinoma Cells through the Opposing Regulation of uPA and PAI-1Semantic proximity Read ↗

Historical analysis of PAI-1 from its discovery to its potential role in cell motility and diseaseSemantic proximity Read ↗

The plasminogen activator inhibitor-1 paradox in cancer: a mechanistic understanding.Semantic proximity Read ↗

Extracellular matrix remodeling facilitates obesity-associated cancer progressionSemantic proximity Read ↗

Transforming growth factor‐β1 in intrauterine adhesionSemantic proximity Read ↗

A naturally occurring MTA1 variant sequesters oestrogen receptor-alpha in the cytoplasm.Semantic proximity Read ↗

Talin1 regulates endometrial adhesive capacity through the Ras signaling pathwaySemantic proximity Read ↗

SERPINE1: A Molecular Switch in the Proliferation-Migration Dichotomy in Wound-“Activated” KeratinocytesSemantic proximity Read ↗

High-Risk Endometrial Carcinoma Profiling Identifies TGF-β1 as a Key Factor in the Initiation of Tumor InvasionSemantic proximity Read ↗

The Role of the Plasminogen Activator Inhibitor 1 (PAI1) in Ovarian Cancer: Mechanisms and Therapeutic ImplicationsSemantic proximity Read ↗

Wilms tumor 1 regulates lipid accumulation in human endometrial stromal cells during decidualizationSemantic proximity Read ↗

Dysregulated protease activated receptor 1 (PAR1) promotes metastatic phenotype in breast cancer through HMGA2.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.