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Article

Sectoral activation of glia in an inducible mouse model of autosomal dominant retinitis pigmentosa.

Scientific reports - 12 Oct 2020

Massengill Michael T, Ash Neil F, Young Brianna M, Ildefonso Cristhian J, Lewin Alfred S

Abstract excerpt

Retinitis pigmentosa (RP) is a group of blinding disorders caused by diverse mutations, including in rhodopsin (RHO). Effective therapies have yet to be discovered. The I307N Rho mouse is a light-inducible model of autosomal dominant RP. Our purpose was to describe the glial response in this mouse model to educate future experimentation. I307N Rho mice were exposed to 20,000 lx of light for thirty minutes to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33046772
DOI: 10.1038/s41598-020-73749-y
PMCID: PMC7552392

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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