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Resistance to anticancer vaccination effect is controlled by a cancer cell-autonomous phenotype that disrupts immunogenic phagocytic removal.

Oncotarget - 29 Sept 2015

Garg Abhishek D, Elsen Sanne, Krysko Dmitri V, Vandenabeele Peter, de Witte Peter, Agostinis Patrizia

Abstract excerpt

Immunogenic cell death (ICD) is a well-established instigator of 'anti-cancer vaccination-effect (AVE)'. ICD has shown considerable preclinical promise, yet there remain subset of cancer patients that fail to respond to clinically-applied ICD inducers. Non-responsiveness to ICD inducers could be explained by the existence of cancer cell-autonomous, anti-AVE resistance mechanisms. However such resistance...

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PMID: 26314964
DOI: 10.18632/oncotarget.4754
PMCID: PMC4694957

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