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Article

Cytotoxic T cells swarm by homotypic chemokine signalling

12 Oct 2020

Abstract excerpt

Cytotoxic T lymphocytes (CTLs) are thought to arrive at target sites either via random search or following signals by other leukocytes. Here, we reveal independent emergent behaviour in CTL populations attacking tumour masses. Primary murine CTLs coordinate their migration in a process reminiscent of the swarming observed in neutrophils. CTLs engaging cognate targets accelerate the recruitment of distant T cells...

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PMID: 33046212
DOI: 10.7554/elife.56554

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