Article
Single Cell Phenotyping Reveals Heterogeneity Among Hematopoietic Stem Cells Following Infection.
Stem cells (Dayton, Ohio) - 1 Nov 2017
MacLean Adam L, Smith Maia A, Liepe Juliane, Sim Aaron, Khorshed Reema, Rashidi Narges M, Scherf Nico, Krinner Axel, Roeder Ingo, Lo Celso Cristina, Stumpf Michael P H
Abstract excerpt
The hematopoietic stem cell (HSC) niche provides essential microenvironmental cues for the production and maintenance of HSCs within the bone marrow. During inflammation, hematopoietic dynamics are perturbed, but it is not known whether changes to the HSC-niche interaction occur as a result. We visualize HSCs directly in vivo, enabling detailed analysis of the 3D niche dynamics and migration patterns in murine...
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