Article
Analysis of a phase-variable restriction modification system of the human gut symbiont Bacteroides fragilis.
Nucleic acids research - 4 Nov 2020
Ben-Assa Nadav, Coyne Michael J, Fomenkov Alexey, Livny Jonathan, Robins William P, Muniesa Maite, Carey Vincent, Carasso Shaqed, Gefen Tal, Jofre Juan, Roberts Richard J, Comstock Laurie E, Geva-Zatorsky Naama
Abstract excerpt
The genomes of gut Bacteroidales contain numerous invertible regions, many of which contain promoters that dictate phase-variable synthesis of surface molecules such as polysaccharides, fimbriae, and outer surface proteins. Here, we characterize a different type of phase-variable system of Bacteroides fragilis, a Type I restriction modification system (R-M). We show that reversible DNA inversions within this R-M...
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