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Article

Tyrosine site-specific recombinases mediate DNA inversions affecting the expression of outer surface proteins of Bacteroides fragilis.

Molecular microbiology - 1 Sept 2004

Weinacht Katja G, Roche Hazeline, Krinos Corinna M, Coyne Michael J, Parkhill Julian, Comstock Laurie E

Abstract excerpt

The chromosome of Bacteroides fragilis has been shown to undergo 13 distinct DNA inversions affecting the expression of capsular polysaccharides and mediated by a serine site-specific recombinase designated Mpi. In this study, we demonstrate that members of the tyrosine site-specific recombinase family, conserved in B. fragilis, mediate additional DNA inversions of the B. fragilis genome. These DNA invertases...

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Identifiers

PMID: 15387812
DOI: 10.1111/j.1365-2958.2004.04219.x

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