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Article

Prevalence and significance of M541L single nucleotide polymorphism in the central European cohort of gastrointestinal stromal tumor patients.

Journal of cancer research and clinical oncology - 1 Apr 2021

Jasek Karin, Grendar Marian, Stanclova Andrea, Malicherova Bibiana, Kasubova Ivana, Burjanivova Tatiana, Szepe Peter, Ciccocioppo Rachele, Rodrigo Luis, Prosecky Robert, Kruzliak Peter, Plank Lukas, Lasabova Zora

Abstract excerpt

BACKGROUND: Single nucleotide polymorphisms can create a genetic microenvironment in some tumors that affects the course of treatment, resistance, etc. Whether single nucleotide polymorphisms have an impact on gastrointestinal stromal tumor (GIST) development and disease progression is not yet accurately verified. KIT SNPM541L in exon 10 correlates with a worse prognosis of many cancers. The impact of KIT...

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PMID: 33044628
DOI: 10.1007/s00432-020-03410-8

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