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Article

Comparison of methods for in-house screening of HLA-B*57:01 to prevent abacavir hypersensitivity in HIV-1 care.

PloS one - 1 Jan 2015

De Spiegelaere Ward, Philippé Jan, Vervisch Karen, Verhofstede Chris, Malatinkova Eva, Kiselinova Maja, Trypsteen Wim, Bonczkowski Pawel, Vogelaers Dirk, Callens Steven, Ruelle Jean, Kabeya Kabamba, De Wit Stephane, Van Acker Petra, Van Sandt Vicky, Emonds Marie-Paule, Coucke Paul, Sermijn Erica, Vandekerckhove Linos

Abstract excerpt

Abacavir is a nucleoside reverse transcriptase inhibitor used as part of combination antiretroviral therapy in HIV-1-infected patients. Because this drug can cause a hypersensitivity reaction that is correlated with the presence of the HLA-B*57:01 allotype, screening for the presence of HLA-B*57:01 is recommended before abacavir initiation. Different genetic assays have been developed for HLA-B*57:01 screening,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25874872
DOI: 10.1371/journal.pone.0123525
PMCID: PMC4398410

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