Article
Expanding spectrum of "spitzoid" lesions: a small series of 4 cases with MAP2K1 mutations.
Virchows Archiv : an international journal of pathology - 1 Jul 2021
Kerckhoffs K G P, Aallali T, Ambarus C A, Sigurdsson V, Jansen A M L, Blokx W A M
Abstract excerpt
The molecular background of a significant proportion of spitzoid neoplasms is still unknown. Recently, activating mutations in MAP2K1 have been described in a few spitzoid lesions, but not in benign Spitz nevi. We report four cases of melanocytic tumors with spitzoid features in which a MAP2K1 mutation was detected. The lesions did not show a single distinct phenotype and ranged from benign to malignant. Two...
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