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Article

Pathways Activated during Human Asthma Exacerbation as Revealed by Gene Expression Patterns in Blood

14 Jul 2011

Abstract excerpt

BACKGROUND: Asthma exacerbations remain a major unmet clinical need. The difficulty in obtaining airway tissue and bronchoalveolar lavage samples during exacerbations has greatly hampered study of naturally occurring exacerbations. This study was conducted to determine if mRNA profiling of peripheral blood mononuclear cells (PBMCs) could provide information on the systemic molecular pathways involved during...

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PMID: 21779351
DOI: 10.1371/journal.pone.0021902

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