Article
Strong evidence of a genetic determinant for mammographic density, a major risk factor for breast cancer.
Cancer research - 1 Sept 2007
Vachon Celine M, Sellers Thomas A, Carlson Erin E, Cunningham Julie M, Hilker Christopher A, Smalley Regenia L, Schaid Daniel J, Kelemen Linda E, Couch Fergus J, Pankratz V Shane
Abstract excerpt
Increased mammographic density (MD), the proportion of dense tissue visible on a mammogram, is a strong risk factor for breast cancer, common in the population and clusters in families. We conducted the first genome-wide linkage scan to identify genes influencing MD. DNA was obtained from 889 relatives (756 women, 133 men) from 89 families. Percent MD was estimated on 618 (82%) female family members using a...
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