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Article

Heat Shock Protein-90 Inhibition Alters Activation of Pancreatic Stellate Cells and Enhances the Efficacy of PD-1 Blockade in Pancreatic Cancer.

Molecular cancer therapeutics - 1 Jan 2021

Zhang Yuchen, Ware Michael B, Zaidi Mohammad Y, Ruggieri Amanda N, Olson Brian M, Komar Hannah, Farren Matthew R, Nagaraju Ganji Purnachandra, Zhang Chao, Chen Zhengjia, Sarmiento Juan M, Ahmed Rafi, Maithel Shishir K, El-Rayes Bassel F, Lesinski Gregory B

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) has a prominent fibrotic stroma, which is a result of interactions between tumor, immune and pancreatic stellate cells (PSC), or cancer-associated fibroblasts (CAF). Targeting inflammatory pathways present within the stroma may improve access of effector immune cells to PDAC and response to immunotherapy. Heat shock protein-90 (Hsp90) is a chaperone protein and a versatile...

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Source

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Identifiers

PMID: 33037138
DOI: 10.1158/1535-7163.MCT-19-0911
PMCID: PMC7790996

Genes

CD4
IL6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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